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KMID : 1007520090180020556
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Food Science and Biotechnology
2009 Volume.18 No. 2 p.556 ~ p.560
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Anti-biofilm Activity of Xanthorrhizol Isolated from Curcuma xanthorrhiza Roxb. against Bacterial Biofilms Formed by Saliva and Artificial Multi-species Oral Strains
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Yanti
Rukayadi Yaya
Lee Kwan-Hyoung
Han Sung-Hwa
Hwang Jae-Kwan
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Abstract
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Xanthorrhizol, a sesquiterpene isolated from Curcuma xanthorrhiza Roxb., was used to investigate its effect onreducing the saliva and multi-species oral biofilms consisting of Streptococcus mutans, Streptococcus sanguis, and Actinomycesviscosus by anti-biofilm and confocal laser scanning microscopy (CLSM) assays. Xanthorrhizol exhibited significant anti-biofilm activity in the dose- and time-dependent manners. Exposure to 2 and 5μg/mL xanthorrhizol for 30min remained<50% of saliva and multi-species biofilms formed for 24hr. In addition, exposure to 10μg/mL xanthorrhizol for 30minreduced 65 and 77% of 24hr saliva and multi-species oral biofilms, respectively. CLSM results visually demonstrated thatxanthorrhizol reduced bacterial viability in the saliva and multi-species oral biofilms. These results suggest that C.xanthorrhiza Roxb. containing xanthorrhizol with strong anti-biofilm activity can be employed as a plant source for oral carefunctional foods.
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KEYWORD
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anti-biofilm activity, Curcuma xanthorrhiza Roxb., xanthorrhizol, oral biofilm
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